THE AUDITORY MODELING TOOLBOX

Applies to version: 0.9.9

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roenne2012_tonebursts - Simulate tone burst evoked ABR wave V latencies

Program code:

function [waveVlat]  = roenne2012_tonebursts(stim_level,varargin)
%roenne2012_tonebursts  Simulate tone burst evoked ABR wave V latencies
%   Usage: [waveVamp, waveVlat]  = roenne2012_tonebursts(flag)
%
%   Output parameters:
%     waveVlat   : Latency of simulated ABR wave V peak.
%
%   ROENNE2012_TONEBURSTS(stim_level) simulates ABR responses to tone burst
%   stimuli using the ABR model of Rønne et al. (2012) for a range of
%   given stimulus levels.
%
%   Fig. 5 of Rønne et al. (2012) can be reproduced. Simulations are
%   compared to data from Neely et al. (1988) and Harte et al. (2009). Tone
%   burst stimuli are defined similar to Harte et al. (2009). Tone burst
%   center frequencies are: 1, 1.5, 2, 3, 6 and 8 kHz.
%
%   The flag may be one of:
%
%     'plot'    Plot main figure (fig 6 or 7).
%
%     'plot2'   Plot extra figures for all individual simulations (3
%               figures x stimulus levels x number of chirps).
%
%     'noplot'  Do not plot main figure (fig 6 or 7). This is the default.
%
%     'fig5'    Plot Fig. 5 (Rønne et al., 2012). Latency of simulated ABR
%               wave V's compared to Neely et al. (1988) and Harte et al.
%               (2009) reference data.
%
%     'stim_level',sl  Simulated levels. Default: Stimulus levels as
%                      chosen by Rønne et al. (2012), 40 to 100 dB pe SPL
%                      in steps of 10 dB. 
%
%   Example:
%   --------
%
%   Figure 5 of Roenne et al. (2012) can be displayed using:
%
%     roenne2012_tonebursts(40:10:100,'plot');
%
%   References:
%     C. Elberling, J. Calloe, and M. Don. Evaluating auditory brainstem
%     responses to different chirp stimuli at three levels of stimulation. J.
%     Acoust. Soc. Am., 128(1):215-223, 2010.
%     
%     J. Harte, G. Pigasse, and T. Dau. Comparison of cochlear delay
%     estimates using otoacoustic emissions and auditory brainstem responses.
%     J. Acoust. Soc. Am., 126(3):1291-1301, 2009.
%     
%     F. M. Rønne, T. Dau, J. Harte, and C. Elberling. Modeling auditory
%     evoked brainstem responses to transient stimuli. The Journal of the
%     Acoustical Society of America, 131(5):3903-3913, 2012. [1]http ]
%     
%     M. S. A. Zilany and I. C. Bruce. Representation of the vowel (epsilon)
%     in normal and impaired auditory nerve fibers: Model predictions of
%     responses in cats. J. Acoust. Soc. Am., 122(1):402-417, jul 2007.
%     
%     References
%     
%     1. http://scitation.aip.org/content/asa/journal/jasa/131/5/10.1121/1.3699171
%     
%
%   Url: http://amtoolbox.sourceforge.net/amt-0.9.9/doc/modelstages/roenne2012_tonebursts.php

% Copyright (C) 2009-2015 Piotr Majdak and the AMT team.
% This file is part of Auditory Modeling Toolbox (AMT) version 0.9.9
%
% This program is free software: you can redistribute it and/or modify
% it under the terms of the GNU General Public License as published by
% the Free Software Foundation, either version 3 of the License, or
% (at your option) any later version.
%
% This program is distributed in the hope that it will be useful,
% but WITHOUT ANY WARRANTY; without even the implied warranty of
% MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE.  See the
% GNU General Public License for more details.
%
% You should have received a copy of the GNU General Public License
% along with this program.  If not, see <http://www.gnu.org/licenses/>.

definput.flags.plot={'noplot','plot','plot2'};
[flags,kv]  = ltfatarghelper({},definput,varargin);

%% Init
fsmod    = 200000;      % AN model fs

% length of modelling [ms]
modellength  = 40;                                                   

% load Unitary Response
[ur,fs]=data_roenne2012;

% Output filter corresponding to recording settings (see Elberling et al
% 2010 section 3)
b=fir1(200,[100/(fs/2),3000/(fs/2)]);
a=1;

% Center Frequencies of stimuli
CF = [1000, 1500, 2000, 3000 ,6000, 8000];                 


% Load tone burst stimuli, identical to Harte et al. (2009)
[Hartestim,fsstim]  = data_harte2009;

%% ABR model

% Loop over stimulus levels
for L = 1:length(stim_level)
  TB_lvl = stim_level(L);
  
  % Loop over stimulus center frequencis
  for F = 1:length(CF) 
    
    % Read tone burst of current CF
    stimread=Hartestim.(['gp' num2str(CF(F))]);
    stim                = zeros(fsstim*modellength/1000,1);     
    
    % Create stimulus with tone burst and concatenated zeros =>
    % combined length = "modellength"
    stim(1:length(stimread)) = stimread;                                
    
    % call AN model, note that lots of extra outputs are possible 
    [ANout,vFreq] = zilany2007(TB_lvl, stim, fsstim,fsmod);    
    
    % subtract 50 due to spontaneous rate
    ANout = ANout-50;                                     
    
    % Sum in time across fibers, summed activity pattern
    ANsum = sum(ANout',2);                                
    
    % Downsample ANsum to get fs = fs_UR = 32kHz
    ANsum = resample(ANsum,fs,fsmod);                     
    
    % Simulated potential = UR * ANsum (* = convolved)
    simpot = filter(ur,1,ANsum);                           
    
    % apply output filter similar to the recording conditions in
    % Elberling et al. (2010)
    simpot = filtfilt(b,a,simpot);                         
    
    % Find max peak value (wave V)
    maxpeak  = max(simpot);                                  
    
    % Find corresponding time of max peak value (latency of wave V)
    waveVlat(F,L) = find(simpot == maxpeak);                 
    
    %% PLOTS, extra plots created for all conditions used, i.e. three
    % plots for each stimulus level x center frequency. If this
    % is switched on and all other variables are set to default,
    % 7 (levels) x 6 (CFs) x 3 (different figures) = 126 figures will
    % be created
    if flags.do_plot2     
      % Plot ABR (simpot)
      t = 1e3.*[0:length(simpot)-1]./fs;
      figure, plot(t-3.5,simpot,'k','linewidth',2)
      xlabel('time [ms]'), set(gca, 'fontsize',12)
      title(['Simulated ABR ( ' num2str(CF(F)) 'Hz,' num2str(TB_lvl) 'dB)'])
      
      % PLOT ANgram
      figure,  set(gca, 'fontsize',12),imagesc(ANout), 
      title(['ANgram, level = ' num2str(TB_lvl) 'dB, CF = ' num2str(CF(F))])
      ylabel('model CF'),xlabel('time [ms]'), xlabel('time [ms]')
      set(gca,'YTick',[1 100 200 300 400 500]),
      set(gca,'YTicklabel',round(vFreq([1 100 200 300 400 500])))
      set(gca,'XTick',(700:500:10000)),
      set(gca,'XTicklabel',(0:500:9500)/fsmod*1000-3.5)
      colorbar
      
      % PLOT ANURgram
      figure,
      ANUR = resample(ANout',fs,fsmod);
      ANUR = filter(ur,1,ANUR);
      imagesc(ANUR'),ylabel('model CF'),
      set(gca,'YTick',[1 100 200 300 400 500]),xlabel('time [ms]'),
      set(gca,'YTicklabel',round(vFreq([1 100 200 300 400 500]))), 
      set(gca,'XTick',(105:150:1500)),
      set(gca,'XTicklabel',(0:150:1350)/fs*1000-3.5)
      colorbar, title(['AN-UR gram, level = ' num2str(TB_lvl) 'dB, CF = ' num2str(CF(F))])
      
    end
  end
end

offset      = 3.5 ;        % stimuli delayed 3.5ms from start
waveVlat    = waveVlat*1000/fs-offset;

if flags.do_plot
  
  ClickLatency = roenne2012_click(stim_level); 
  
  figure;
  plot_roenne2012toneburst(waveVlat,click_latency);
  
end