function output = laback2023(insig, fs, varargin)
%LABACK2023 Contextual lateralization based on interaural level differences
%
% Usage: [outsig, fc] = laback2023(insig,fs);
% [outsig, fc] = laback2023(insig,fs,...);
% [outsig, fc, params] = laback2023(insig,fs,...);
%
% Input parameters:
% insig : input acoustic signal.
% fs : sampling rate.
%
% Output parameters:
% outsig : output acoustic signal.
% fc : filter bank center frequencies.
%
% LABACK2023(insig,fs) computes the internal representation of the
% signal insig sampled with a frequency of fs Hz.
%
% [outsig,fc,mfc]=LABACK2023(...) additionally returns the center
% frequencies of the filter bank and the center frequencies of the
% modulation filterbank.
%
% References:
% B. Laback. Contextual lateralization based on interaural level
% differences is preshaped by the auditory periphery and predominantly
% immune against sequential segregation. Trends in Hearing,
% 27:23312165231171988, 2023. PMID: 37161352. [1]arXiv | [2]www: ]
%
% C. J. Smalt, M. G. Heinz, and E. A. Strickland. Modeling the
% Time-Varying and Level-Dependent Effects of the Medial Olivocochlear
% Reflex in Auditory Nerve Responses. Journal of the Association for
% Research in Otolaryngology, 15(2):159--173, Apr. 2014. [3]http ]
%
% M. S. A. Zilany, I. C. Bruce, and L. H. Carney. Updated parameters and
% expanded simulation options for a model of the auditory periphery. The
% Journal of the Acoustical Society of America, 135(1):283--286, Jan.
% 2014.
%
% References
%
% 1. http://arxiv.org/abs/ https://doi.org/10.1177/23312165231171988
% 2. https://doi.org/10.1177/23312165231171988
% 3. https://doi.org/10.1007/s10162-013-0430-z
%
%
% Url: http://amtoolbox.org/amt-1.4.0/doc/models/laback2023.php
% #StatusDoc: Unknown
% #StatusCode: Unknown
% #Verification: Unknown
% #Requirements: MATLAB MEX M-Signal
% #Author: Bernhard Laback (2023): Original version
% #Author: Alejandro Osses (2023): adapted to AMT 1.4
% This file is licensed unter the GNU General Public License (GPL) either
% version 3 of the license, or any later version as published by the Free Software
% Foundation. Details of the GPLv3 can be found in the AMT directory "licences" and
% at <https://www.gnu.org/licenses/gpl-3.0.html>.
% You can redistribute this file and/or modify it under the terms of the GPLv3.
% This file is distributed without any warranty; without even the implied warranty
% of merchantability or fitness for a particular purpose.
% ------ Checking of input parameters ------------
% load defaults
definput.import={'laback2023'};
% definput.importdefaults={''};
definput.keyvals.subfs=[];
[flags,keyvals] = ltfatarghelper({},definput,varargin);
model = keyvals.model;
precmode = keyvals.precmode;
AdaptMode = keyvals.AdaptMode;
Modeldelay= keyvals.Modeldelay;
Onset = keyvals.Onset;
N_samples = size(insig,1); % length of the time dimension
noiseILDvec = keyvals.noiseILDvec;
gapvec = keyvals.gapvec;
length_stimTarg = keyvals.length_stimTarg;
if isempty(length_stimTarg)
if precmode == 0
length_stimTarg = length(insig);
else
error('The length of the original stimTarg (length_stimTarg) needs to be specified');
end
end
% ------ do the computation -------------------------
if flags.do_MOC
MOCstat = 2;
end
if flags.do_no_MOC
MOCstat = 1;
end
fiberType = keyvals.fiberType;
switch model
case 1
nrep = 20; % 20 repetitions
dt = 1/fs;
dur_sim = N_samples*1.5/fs;
spont = keyvals.spontvec(fiberType);
%%% For smalt2014, cohc is always 1
keyvals.cohc=1; % maximum OHC activity
switch MOCstat
case 1
% MOC off
mocr_max = 0; % minimum gain reduction (relative to COHC value)
case 2
% MOC on
mocr_max=keyvals.mocr_max_def; % maximum gain reduction (relative to COHC value)
end
if keyvals.BinMOC % binaural efferent model fit 2:1 dB ipsi/contra ratio
mocr_threshold = -130.5076; % 2:1
mocr_slope = .0163840; % 2:1
mocr_binauralratio = [0.4654 0.2332] ;% 2:1 => differs slightly from Tab. 1
else %contralateral MOC only
warning('Not validated yet...')
mocr_threshold = -130.5076; % 2:1
mocr_slope = .0163840; % 2:1
mocr_binauralratio = [0 0.2332] ;% 2:1 => differs slightly from Tab. 1
end
flags_z_fixed = {keyvals.CF_Model, nrep, dt, dur_sim, keyvals.cohc, keyvals.cihc, ...
spont,mocr_max,mocr_threshold,mocr_slope,mocr_binauralratio,keyvals.shocks};
%%% Part 1 ------------------------------------
insig = transpose(insig); % needs to be a row array
try
[timeout,meout,mocr,c1filterout,c2filterout, ...
c1vihc,c2vihc,vihc,synout,psth500k] = smalt2014(insig,flags_z_fixed{:});
catch
error('smalt2014 failed')
end
% numears = size(stim,1); % 1=monaural, 2=binaural
% psthbins = round(kv.psthbinwidth*fs); % number of psth500k bins per psth bin
%psthtime = timeout(1:psthbins:end); % time vector for psth
%pr = squeeze(sum(reshape(psth500k,numears,psthbins,length(psth500k)/psthbins),2))/kv.nrep; % pr of spike in each bin
%psth = pr/kv.psthbinwidth; % psth in units of spikes/s
%%% Part 2 ------------------------------------
% Obtains 'diffvec'
%use synapse for determining internal ILD
if precmode == 0
wstart=Modeldelay;
wend = Modeldelay + length_stimTarg;
elseif precmode == 1
%Optimal
wstart = Modeldelay + length(noiseILDvec) + length(gapvec);
wend = Modeldelay + length(noiseILDvec) + length(gapvec) + length_stimTarg;
end
MedWin=400; %window length for running average (smooting of response)
diffpsth = medfilt1(synout(1,wstart:wend),MedWin) - medfilt1(synout(2,wstart:wend), MedWin);
%use synapse output
%Separate into rectangular windows, weight output in each
%window and integrate across windows
WL = fs*0.002; %window duration (in ms)
Overlap = 50; %overlap of windows in percent
Shift = WL*Overlap/100; %shift between successive windows
%number of windows (trailing portion (WNumb*(Shift)+Shift) ignored, if no integer number fits)
WNumb = floor(length(synout(1,wstart:wend))/Shift - 1);
WBeg = wstart;
Wvec = zeros(2, WNumb);
for i_wind = 1:WNumb
WEnd = WBeg+WL-1;
W_L = mean(synout(1,WBeg:WEnd)); %mean rate in current L window
W_R = mean(synout(2,WBeg:WEnd)); %mean rate in current R window
Wvec(1, i_wind) = W_L; %for analyzing monaural responses
Wvec(2, i_wind) = W_R; %for analyzing monaural responses
MeanRate = (W_L + W_R)/2; %needed for determining weight
WBeg = WBeg+Shift;
end
%Without windowing and MED-filtering
RespL = mean(synout(1,wstart:wend)); %wend
RespR = mean(synout(2,wstart:wend)); %wend
diffvec = RespL - RespR;
diffvec_description = 'diffvec';
case 2
% definput.import = {'zilany2014'};
% [fg_zilany, kv_zilany] = ltfatarghelper({},definput,varargin);
%%% Part 1 ------------------------------------
switch MOCstat
case 1
% MOC off
keyvals.cohc=0; % no OHC activity %minimum gain reduction (relative to COHC value)
case 2
% MOC on
keyvals.cohc=1; % maximum OHC activity %maximum gain reduction (relative to COHC value)
end
flags_z_common = {keyvals.CF_Model,'fiberType',fiberType, 'cohc', keyvals.cohc};
% Left: Ipsilateral with 20 fibers, contralateral with 8 fibers:
[synout_I_L,psth_I_L] = zilany2014(insig(:,1),fs, flags_z_common{:}, 'nrep', 20);
[synout_C_L,psth_C_L] = zilany2014(insig(:,1),fs, flags_z_common{:}, 'nrep', 8);
% Right: Ipsilateral with 8 fibers, contralateral with 20 fibers:
[synout_I_R,psth_I_R] = zilany2014(insig(:,2),fs, flags_z_common{:}, 'nrep', 8);
[synout_C_R,psth_C_R] = zilany2014(insig(:,2),fs, flags_z_common{:}, 'nrep', 20);
disp('')
% Contra LSO: Left(8), right(20);
%%% Part 2 ------------------------------------
if precmode == 0
switch AdaptMode
case 0
wstart=Modeldelay + Onset*fs;
wend = Modeldelay + N_samples;
case 1
wstart=Modeldelay + length(PrecPrecVec) + length(kv.gapvecLong) + Onset*Fs;
wend = Modeldelay + length(PrecPrecVec) + length(kv.gapvecLong) + length_stimTarg;
end
elseif precmode == 1
switch AdaptMode
case 0
wstart = Modeldelay + length(noiseILDvec) + length(gapvec) + Onset*fs; %240 corresponding to processing delay => %adding 15000 samples reverts contra/ipsi effect (as does subtractin) => how possible.
wend = Modeldelay + length(noiseILDvec) + length(gapvec) + length_stimTarg;
case 1
wstart = Modeldelay + length(noiseILDvec)*2 + length(gapvec) + length(kv.gapvecLong) + Onset*fs; %240 corresponding to processing delay => %adding 15000 samples reverts contra/ipsi effect (as does subtractin) => how possible.
wend = Modeldelay + length(noiseILDvec)*2 + length(gapvec) + length(kv.gapvecLong) + length_stimTarg;
end
end
MedWin=400; %window length for running average (smooting of response)
% Mean of the 'moving average':
RespL_tmp = mean(medfilt1(synout_I_L(wstart:wend),MedWin));
RespR_tmp = mean(medfilt1(synout_C_R(wstart:wend),MedWin));
%Left LSO
I_L=psth_I_L(wstart:wend);
I_R=psth_I_R(wstart:wend);
%Right LSO
C_L=psth_C_L(wstart:wend);
C_R=psth_C_R(wstart:wend);
switch keyvals.ANmode
case 1
RespL = RespL_tmp;
RespR = RespR_tmp;
% as used to predict LSO model based on Zilany2014
% LSO model (Ashida, 2016)
[spOut_I, ~] = ashida2016_LSOmodelCOC(I_L, I_R, 1/fs);
[spOut_C, ~] = ashida2016_LSOmodelCOC(C_R, C_L, 1/fs);
spOutVec_I = numel(find(spOut_I));
spOutVec_C = numel(find(spOut_C));
diffvec = spOutVec_I - spOutVec_C;
diffvec_description = 'diffvec_LSO (Ashida 2016)';
case 2
% %used to predict spike-based AN model
error('Not validated yey by AO')
% RespL(MOCstat, i_ILD) = mean(psth_I_L(wstart:wend));
% RespR(MOCstat, i_ILD) = mean(psth_I_R(wstart:wend));
% diffvec_LSO(MOCstat, i_ILD) = RespL(MOCstat, i_ILD) - RespR(MOCstat, i_ILD);
case 3
% used to predict synapse-based AN model
RespL = mean(psth_I_L(wstart:wend));
RespR = mean(psth_I_R(wstart:wend));
diffvec = RespL_tmp - RespR_tmp;
diffvec_description = 'diffvec_LSO';
end
end
output.RespL = RespL;
output.RespR = RespR;
output.diffvec = diffvec;
output.diffvec_description = diffvec_description;