THE AUDITORY MODELING TOOLBOX

Applies to version: 1.6.0

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VERHULST2018_IHCTRANSDUCTION
ihc transduction in Verhulst et al. 2018

Description:

Inner hair cell transduction as used in Verhulst et al. models. Vihc represents the inner-hair-cell membrane potential in Volts.

The following IHC transduction models are implemented here:

version_year = 2018 ('verhulst2018b')

version_year = 2015

The 2018 model Vihc is obtained from the interplay between K+ ion channels and mechanoelectrical transduction (MET) currents. This model is described in verhulst2018a (Appendix A) and is based on the description/validation described in altoe2018. The influence of calcium channels is not accounted in this script but it is in verhulst2018_auditorynerve.m, where the effective exocystosis rate is controlled by Ca-related parameters. In this script an effect of the calcium channels could be added by setting a leak current but in the current validation such Ikeak is not active (because Gleak is 0).

License:

This model is licensed under the UGent Academic License. Further usage details are provided in the UGent Academic License which can be found in the AMT directory "licences" and at <https://raw.githubusercontent.com/HearingTechnology/Verhulstetal2018Model/master/license.txt>.

References:

S. Verhulst, A. Altoè, and V. Vasilkov. Functional modeling of the human auditory brainstem response to broadband stimulation. Hearing Research, 360:55--75, 2018.

A. Altoè, V. Pulkki, and S. Verhulst. The effects of the activation of the inner-hair-cell basolateral k+ channels on auditory nerve responses. hearingresearch, 364:68--80, 2014.